RNF139
Sign in to saveAlso known as HRCA1, RCA1, TRC8, ring finger protein 139
RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.
In the Vinony graph
Within Vinony's link graph, RNF139 is referenced by 3 other articles, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 8 and RING finger proteins.
Its subject is documented across 6 Wikipedia language editions.
Gene data
RNF139- Name
- ring finger protein 139
- Type
- protein-coding
- Position
- 124,474,699–124,488,618 (+)
- Aliases
- HRCA1, RCA1, TRC8
- Ensembl
- ENSG00000170881
- RefSeq RNA
- NM_007218.4, XM_047421310.1, XM_054333043.1, XM_054359682.1
- RefSeq protein
- NP_009149.2, XP_047277266.1, XP_054189018.1, XP_054215657.1
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ring finger protein 139
- Symbol
- RNF139
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:124,474,699-124,488,618
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 5222
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11236
- genomic end
- 124488618
- genomic start
- 124474880
- chromosome
- human chromosome 8
- cytogenetic location
- 8q24.13
- expressed in
- Achilles tendon
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].
Excerpted from Wikipedia’s “RNF139” article, available under the CC BY-SA 4.0 licence.