RNF139

Also known as HRCA1, RCA1, TRC8, ring finger protein 139

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.

Gene data

RNF139

Name: ring finger protein 139
Type: protein-coding
Aliases: HRCA1, RCA1, TRC8

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

ring finger protein 139

Symbol: RNF139
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:124,474,699-124,488,618
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 5222
exact match: identifiers.org/ncbigene/11236
genomic end: 124488618
genomic start: 124474880
cytogenetic location: 8q24.13

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RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].