TIMP3

Also known as HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.

Gene data

TIMP3

Name: TIMP metallopeptidase inhibitor 3
Type: protein-coding
Position: 32,801,576–32,863,042 (+)
Aliases: HSMRK222, K222, K222TA2, SFD
Ensembl: ENSG00000100234
RefSeq RNA: NM_000362.5
RefSeq protein: NP_000353.1

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

response to hormone negative regulation of extracellular matrix disassembly negative regulation of extracellular matrix disassembly response to cytokine negative regulation of proteolysis negative regulation of membrane protein ectodomain proteolysis negative regulation of membrane protein ectodomain proteolysis

Molecular function

protein binding metalloendopeptidase inhibitor activity metalloendopeptidase inhibitor activity metalloendopeptidase inhibitor activity

Cellular component

extracellular region extracellular region basement membrane nucleus extracellular matrix extracellular matrix extracellular matrix platelet dense granule lumen

Pathways

Proteoglycans in cancer - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Hemostasis Platelet degranulation Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+Matrix Metalloproteinases Angiogenesis Oncostatin M Signaling Pathway Vitamin D Receptor Pathway

via MyGene.info

Gene · Ensembl

TIMP metallopeptidase inhibitor 3

Symbol: TIMP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:32,801,576-32,863,042
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 36322
exact match: identifiers.org/ncbigene/7078
genomic end: 32863041
genomic start: 32801705
cytogenetic location: 22q12.3

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Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.