TMEM59
Sign in to saveAlso known as C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.
In the Vinony graph
Within Vinony's link graph, TMEM59 is referenced by 2 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
TMEM59- Name
- transmembrane protein 59
- Type
- protein-coding
- Position
- 54,026,681–54,053,504 (−)
- Aliases
- C1orf8, DCF1, HSPC001, PRO195, UNQ169
- Ensembl
- ENSG00000116209
- RefSeq RNA
- NM_001305043.2, NM_001305049.1, NM_001305050.2, NM_001305051.1, NM_001305052.1
- RefSeq protein
- NP_001291972.1, NP_001291978.1, NP_001291979.1, NP_001291980.1, NP_001291981.1
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
transmembrane protein 59
- Symbol
- TMEM59
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:54,026,681-54,053,504
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 3583
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9528
- genomic end
- 54519177
- genomic start
- 54497347
- chromosome
- human chromosome 1
- cytogenetic location
- 1p32.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.
TMEM59 is a membrane bound protein that is localized to the Golgi apparatus. The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease. Moreover, TMEM59 has been shown to potentiate wnt signaling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficacy of wnt signaling.
Excerpted from Wikipedia’s “TMEM59” article, available under the CC BY-SA 4.0 licence.