TPX2
Sign in to saveAlso known as C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4
Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase.
Gene data
TPX2- Name
- TPX2 microtubule nucleation factor
- Type
- protein-coding
- Position
- 31,739,248–31,801,805 (+)
- Aliases
- C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100
- Ensembl
- ENSG00000088325
- RefSeq RNA
- NM_012112.5, XM_011528697.3, XM_011528699.3, XM_011528700.4, XM_047440017.1
- RefSeq protein
- NP_036244.2, XP_011526999.1, XP_011527001.1, XP_011527002.1, XP_047295973.1
Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TPX2 microtubule nucleation factor
- Symbol
- TPX2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:31,739,248-31,801,805
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TPX2 PDB 1ol5.png
Show 7 more facts
- HomoloGene ID
- 8107
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/22974
- genomic end
- 30389608
- genomic start
- 30327074
- chromosome
- human chromosome 20
- cytogenetic location
- 20q11.21
Sources (4)
via Wikidata · CC0
~15 min read
Encyclopedic overview
11 sectionsContents
- Key domains of TPX2
- Role in microtubule assembly
- Activation and reciprocation through Aurora A kinase
- Role in cleavage arrest and interaction with Eg5
- Binding with Xlp2
- Regulation of TPX2 in the cell cycle
- Role in the nucleus
- Relevance in cancer
- References
- Further reading
- External links
Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase.
== Key domains of TPX2 == TPX2 has been reported to have two NLS-containing domains that mediate its localization to microtubules; one in the amino-terminal domain, and the other in the carboxy-terminal domain. In addition to an NLS, the carboxy-terminal domain of TPX2 consists of tandem repeats that cover over two-thirds of the protein and are computationally predicted to consist of predominantly alpha-helical content. This region can be further divided into five clusters of conserved residues separated by unstructured regions: α3-7. α3-6 all contain a central α-helical region that is followed by a characteristic "FKARP" motif. α7 is longer and exhibits a long α-helical stretch that is computationally predicted to form a coiled coil. Lastly, the final 35 amino acids of the carboxy-terminus of TPX2 are responsible for interacting with tetrameric kinesin Eg5.
Excerpted from Wikipedia’s “TPX2” article, available under the CC BY-SA 4.0 licence.