TRIM16
Sign in to saveAlso known as EBBP, tripartite motif containing 16
Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.
Gene data
TRIM16- Name
- tripartite motif containing 16
- Type
- protein-coding
- Aliases
- EBBP
The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017].
via MyGene.info
Gene · Ensembl
tripartite motif containing 16
- Symbol
- TRIM16
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:15,627,950-15,684,311
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 2 more facts
- HomoloGene ID
- 4726
- exact match
- identifiers.org/ncbigene/10626
Sources (3)
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Tumor suppression
- Cardiac hypertrophy
- References
- Further reading
Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.