trimethoprim
Also known as Monotrim, Proloprin, Trimpex 200, Trimpex, 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine, Proloprim, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, BW-56-72
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travellers' diarrhoea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken orally (swallowed by mouth).
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470615131
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- Trimethoprim.svg
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- skin-invert-image
- Drug.width
- 240
- Drug.alt
- Structural formula of trimethoprim
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- 250
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- Ball-and-stick model of the trimethoprim molecule
- Drug.tradename
- Proloprim, Monotrim, Triprim, others
- Drug.MedlinePlus
- a684025
Article
10 sectionsContents
- Medical uses
- Spectrum of susceptibility
- Side effects
- Common
- Rare
- Contraindications
- Pregnancy
- Mechanism of action
- History
- References
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travellers' diarrhoea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken orally (swallowed by mouth).
Common side effects include nausea, changes in taste, and rash. Rarely it may result in blood problems such as not enough platelets or white blood cells. Trimethoprim may cause sun sensitivity. There is evidence of potential harm during pregnancy in some animals but not humans. It works by blocking folate metabolism via dihydrofolate reductase in some bacteria, preventing creation of bacterial DNA and RNA and leading to bacterial cell death.