TXNDC12

Also known as AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.

Gene data

TXNDC12

Name: thioredoxin domain containing 12
Type: protein-coding
Aliases: AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012].

via MyGene.info

Wikidata facts

Image: Protein TXNDC12 PDB 1sen.png

Sources (3)

Article

2 sections

Contents

References
Further reading

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors (Liu et al., 2003).[supplied by OMIM]