UNC13A
Sign in to saveAlso known as Munc13-1, unc-13 homolog A (C. elegans), unc-13 homolog A
'Unc-13 homolog A (C. elegans)' is a protein that in humans is encoded by the UNC13A gene and in mice by the Munc13-1 gene.
Gene data
UNC13A- Name
- unc-13 homolog A
- Type
- protein-coding
- Aliases
- IDDSF, Munc13-1, NEDHES, NEDSMS
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012].
via MyGene.info
Gene · Ensembl
unc-13 homolog A
- Symbol
- UNC13A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:17,601,327-17,688,382
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/23025
- HomoloGene ID
- 11279
- cytogenetic location
- 19p13.11
- genomic end
- 17799401
- genomic start
- 17601336
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Function
- Protein structure
- Subcellular location
- Interaction
- Clinical significance
- References
- Further reading
'Unc-13 homolog A (C. elegans)' is a protein that in humans is encoded by the UNC13A gene and in mice by the Munc13-1 gene.
== Function == This gene encodes a member of the UNC13 family. UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. In Drosophila melanogaster, the protein has been shown to define the vesicle release site by regulating the coupling distance between synaptic vesicles and calcium channels in cooperation with another isoform, UNC13B. It is particularly important in most glutamatergic-mediated synapses as well as GABA-mediated synapses. It plays a role in dendrite formation by melanocytes and in secretory granule priming in insulin secretion.