UQCRC2

Also known as MC3DN5, QCR2, UQCR2, ubiquinol-cytochrome c reductase core protein II, ubiquinol-cytochrome c reductase core protein 2

Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2), also known as QCR2, UQCR2, or MC3DN5 is a protein that in humans is encoded by the UQCRC2 gene. The product of UQCRC2 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", a

Gene data

UQCRC2

Name: ubiquinol-cytochrome c reductase core protein 2
Type: protein-coding
Position: 21,952,636–21,990,814 (+)
Aliases: MC3DN5, QCR2, UQCR2
Ensembl: ENSG00000140740
RefSeq RNA: NM_003366.4
RefSeq protein: NP_003357.2

The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].

Gene Ontology

Biological process

oxidative phosphorylation mitochondrial electron transport, ubiquinol to cytochrome c proteolysis aerobic respiration cellular respiration

Molecular function

metalloendopeptidase activity protein binding metal ion binding

Cellular component

mitochondrion mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane

Pathways

Oxidative phosphorylation - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Prion disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

ubiquinol-cytochrome c reductase core protein 2

Symbol: UQCRC2
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:21,952,636-21,990,814
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 37764
exact match: identifiers.org/ncbigene/7385
genomic start: 21953288
genomic end: 21994981
cytogenetic location: 16p12.2

Sources (4)

via Wikidata · CC0

~3 min read

Article

6 sections

Contents

Structure
Function
Clinical Significance
Interactions
References
Further reading

== Structure == UQCRC2 is located on the p arm of chromosome 16 in position 12.2 and has 14 exons. The UQCRC2 gene produces a 48.4 kDa protein composed of 453 amino acids. UQCRC2 belongs to the peptidase M16 family and UQCRC2/QCR2 subfamily. UQCRC2 has a transit peptide domain. Ubiquinol Cytochrome c Reductase (b-c1 complex) contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). UQCRC2 is part of the hydrophobic core of the b-c1 complex and is necessary for the stabilization of Ubiquinol Cytochrome c Reductase.