uromodulin
Sign in to saveAlso known as Tamm-Horsfall urinary glycoprotein, UMOD, uromucoid, THP
Uromodulin (UMOD),Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine.
Protein · UniProt
Uromodulin
- Gene
- UMOD
- Organism
- Homo sapiens (Human)
- Length
- 640 aa
- Molecular mass
- 69,761 Da
- Evidence
- 1: Evidence at protein level
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515)
Swiss-Prot (reviewed) · via UniProt
Research
1,677 papersvia PubMed
Clinical Trials
11 registered- NANOT_YET_RECRUITINGRole of Uromodulin in Management of Multiple MylomaAssiut University · NCT06876298
- COMPLETEDEstimation of Kidney Function Through Combination of Renal Biomarkers in Blood and Urine of Healthy Infants and Children.University Hospital, Basel, Switzerland · NCT03751397
- WITHDRAWNGlycoproteomic Analysis of Urine in Women Undergoing Spontaneous Preterm DeliveryUniversity of Missouri-Columbia · NCT01348230
- COMPLETEDUrinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney DiseaseAristotle University Of Thessaloniki · NCT06363097
- COMPLETEDStudy to Evaluate Blood and Urine Kidney Injury Markers to Facilitate Early Detection of Renal Adverse Drug Events in Pediatric Cancer Patients Treated With Nephrotoxic ChemotherapyUniversity Hospital, Basel, Switzerland · NCT04308642
- NACOMPLETEDHereditary Tubulointerstitial NephritisAssistance Publique - Hôpitaux de Paris · NCT01312727
Wikidata facts
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- Commons category
- Uromodulin
- exact match
- purl.uniprot.org/uniprot/P07911
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Article
8 sectionsContents
- Protein
- Structure
- Function
- Clinical significance
- History
- References
- Further reading
- External links
Uromodulin (UMOD),Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine.
The human UMOD gene is located on chromosome 16. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.