Structure via PubChem · Public domain (PubChem)
vincamine
Sign in to saveAlso known as vincamidol, (+)-Vincamine, Methyl vincaminate, Pervincamine, Vinkametrin, Devinkan, Devincan, Angiopac
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.
In the Vinony graph
Within Vinony's link graph, vincamine is referenced by 54 other articles, and connects out to International Standard Book Number, digital object identifier and chemical formula.
It sits within the topics Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and Drugs with no legal status.
Its subject is documented across 16 Wikipedia language editions.
Chemical data
- Formula
- C21H26N2O3
- Molecular weight
- 354.4 g/mol
- IUPAC name
- methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate
- SMILES
- CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4[C@](C2)(C(=O)OC)O
- InChIKey
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N
- XLogP
- 2.9
- Polar surface area
- 54.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
523 papers- Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential.Bioorganic & medicinal chemistry · 2023
- Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice.Acta pharmacologica Sinica · 2023
- Vincamine ameliorates hepatic fibrosis via inhibiting S100A4-mediated farnesoid X receptor activation: based on liver microenvironment and enterohepatic circulation dependence.British journal of pharmacology · 2025
- Evaluation of vincamine against Acetylcholinesterase enzyme.Cellular and molecular biology (Noisy-le-Grand, France) · 2022
- Vincamine Mitigates Methotrexate-Induced Liver Fibrosis Model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 354.194
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₁H₂₆N₂O₃
- canonical SMILES
- CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O
- isomeric SMILES
- CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4[C@](C2)(C(=O)OC)O
- subject has role
- vasodilator agent
- Commons category
- Vincamine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
8 sectionsContents
- Uses
- Chemistry
- Synthesis
- Derivatives
- Research
- See also
- References
- External links
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.
==Uses== Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia. In the United States, it is permitted to be sold as a dietary supplement when labeled for use in adults for six months or less. Most common preparations are in the sustained release tablet forms.
Excerpted from Wikipedia’s “vincamine” article, available under the CC BY-SA 4.0 licence.