pentoxifylline
Sign in to saveAlso known as BL-191, Trental®, Pentoxifyllin, Pentoxifyllinum, Oxpentifylline, Pentoxifilina
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It was approved for medical use in 1984 and is available as generic and sold under many brand names worldwide like Trental.
Key facts
- Drug.pregnancy_AU
- B1
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464198476
- Drug.IUPAC_name
- 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione
- Drug.image
- Pentoxifylline.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 180
- Drug.image2
- Pentoxifylline xtal 2005 ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Trental, many other names worldwide
- Drug.MedlinePlus
- a685027
- Drug.licence_US
- Pentoxifylline
- Drug.pregnancy_US
- C
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Research
6,081 papers- Pentoxifylline in dermatology.Journal of cosmetic dermatology · 2023
- Pentoxifylline for intermittent claudication.The Cochrane database of systematic reviews · 2020
- Pentoxifylline.Journal of the American Academy of Dermatology · 1994
- Pentoxifylline review.Journal of the American Podiatric Medical Association · 1987
- Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients.Pharmacology research & perspectives · 2020
via PubMed
Wikidata facts
- Mass
- 278.138
Show 5 more facts
- chemical formula
- C₁₃H₁₈N₄O₃
- Commons category
- Pentoxifylline
- canonical SMILES
- CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
- half-life
- 0.6
- stylized name
- TRENtal
Sources (6)
via Wikidata · CC0
~7 min read
Article
7 sectionsContents
- Medical uses
- Adverse effects
- Mechanism
- Research
- See also
- References
- External links
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It was approved for medical use in 1984 and is available as generic and sold under many brand names worldwide like Trental.
== Medical uses == Its primary use in medicine is to reduce pain, cramping, numbness, or weakness in the arms or legs which occurs due to intermittent claudication, a form of muscle pain resulting from peripheral artery diseases. This is its only FDA, MHRA and TGA-labelled indication. However, pentoxifylline is also recommended for off-label use as an adjunct to compression bandaging for the treatment of chronic venous leg ulcers by the Scottish Intercollegiate Guidelines Network (SIGN) as this has been shown to improve healing rates.