Structure via PubChem · Public domain (PubChem)
enoximone
Sign in to saveAlso known as fenoximone, MDL 17,043, MDL-17,043, MDL-17043, Perfan®, Perfan
Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.
Chemical data
- Formula
- C12H12N2O2S
- Molecular weight
- 248.3 g/mol
- IUPAC name
- 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
- SMILES
- CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC
- InChIKey
- ZJKNESGOIKRXQY-UHFFFAOYSA-N
- XLogP
- 1.6
- Polar surface area
- 83.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, congestive heart failure, coronary artery disease
via ChEMBL · EBI
Research
601 papers- Enoximone.Lancet (London, England) · 1988
- Enoximone.American heart journal · 1990
- Enoximone in status asthmaticus.ERJ open research · 2020
- (Oral) enoximone in asthma.ERJ open research · 2020
- Enoximone. A review of its pharmacological properties and therapeutic potential.Drugs · 1991
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 248.061949
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₂H₁₂N₂O₂S
- canonical SMILES
- CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC
- Commons category
- Enoximone
- defined daily dose
- 1
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
{{Drugbox | Watchedfields = changed | verifiedrevid = 443725104 | IUPAC_name = 4-Methyl-5-{[4-(methylsulfanyl)phenyl]carbonyl}-2,3-dihydro-1H-imidazol-2-one | image = Enoximone.svg | image_class = skin-invert-image
| tradename = Perfan | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = POM | legal_US = | legal_status = | routes_of_administration = Intravenous
Excerpted from Wikipedia’s “enoximone” article, available under the CC BY-SA 4.0 licence.