aminophylline

Also known as aminophilline, Somophyllin, Truphylline, Phyllocontin, Peterphyllin, Aminophylline Dye Free, Aminophylline In Sodium Chloride, Somophyllin-Df

Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate.

Chemical data

Formula: C16H24N10O4
Molecular weight: 420.43 g/mol
IUPAC name: bis(1,3-dimethyl-7H-purine-2,6-dione);ethane-1,2-diamine
SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
InChIKey: FQPFAHBPWDRTLU-UHFFFAOYSA-N
Polar surface area: 191 Å²
H-bond donors: 4
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Protein
First approval: 1940
Admin. routes: oral, parenteral, topical
Indications: Airway obstruction, pulmonary arterial hypertension, altitude sickness, Acute kidney injury

via ChEMBL · EBI

Research

5,694 papers

Aminophylline in pain and migraine.Pain management · 2023
Aminophylline toxicity.Pediatric clinics of North America · 1987
Aminophylline.Anesthesia and analgesia · 1981
Aminophylline treatment in severe, acute asthma. A meta-analysis.JAMA · 1988
The properties of aminophylline.Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association · 2007

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 420.198199
Manufacturer: Pfizer
Has use: medication

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chemical formula: C₁₆H₂₄N₁₀O₄
subject has role: cardiotonic
route of administration: oral administration
medical condition treated: acute bronchitis
canonical SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
MCN code: 2939.59.20
has characteristic: bitterness
Commons category: Aminophylline
significant drug interaction: ciprofloxacin

Sources (3)

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Encyclopedic overview

6 sections

Contents

Medical uses
Side effects
Properties
Pharmacology
References
External links

Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate.

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of airway obstruction from asthma or COPD. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.

Excerpted from Wikipedia’s “aminophylline” article, available under the CC BY-SA 4.0 licence.

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