droxidopa
Sign in to saveAlso known as L-DOPS, Northera®, SM-5688, (-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid, (2S,3R)-3,4-dihydroxy-phenylserine, L-Threodops, SM 5688, threo-Dopaserine
Droxidopa, also known as 'L-threo-dihydroxyphenylserine (L-DOPS) and sold under the brand names Northera and Dops' among others, is sympathomimetic medication which is used in the treatment of hypotension (low blood pressure) and for other indications. It is taken by mouth.
Research
483 papers- Droxidopa.2012
- Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review.Cureus · 2023
- Droxidopa for Vasopressor Weaning in Critically Ill Patients with Persistent Hypotension: A Multicenter, Retrospective, Single-Arm Observational Study.Journal of intensive care medicine · 2025
- Droxidopa in Critical Care: A Systematic Review of an Emerging Off-Label Practice.Critical care research and practice · 2025
- Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases.Expert opinion on pharmacotherapy · 2019
via PubMed
Wikidata facts
- Mass
- 213.063722
Show 6 more facts
- chemical formula
- C₉H₁₁NO₅
- Commons category
- Droxidopa
- canonical SMILES
- C1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O
- World Health Organisation international non-proprietary name
- droxidopa
- isomeric SMILES
- N[C@@H]([C@H](O)C1=CC=C(O)C(O)=C1)C(O)=O
- NCI Thesaurus ID
- C73266
via Wikidata · CC0
~5 min read
Article
12 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Chemistry
- History
- Clinical trials
- Society and culture
- Names
- Research
- See also
- References
- External links
Droxidopa, also known as 'L-threo-dihydroxyphenylserine (L-DOPS) and sold under the brand names Northera and Dops' among others, is sympathomimetic medication which is used in the treatment of hypotension (low blood pressure) and for other indications. It is taken by mouth.
Side effects of droxidopa include headache, dizziness, nausea, and hypertension, among others. Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitter norepinephrine (noradrenaline). Hence, it acts as a non-selective agonist of the α- and β-adrenergic receptors. Unlike norepinephrine, but similarly to levodopa (L-DOPA), droxidopa is capable of crossing the protective blood–brain barrier (BBB).