silodosin

Also known as KMD-3213, Rapaflo®, Silodyx®, Rapilif, Urief, KAD 3213, KMD 3213

Silodosin, sold under the brand name Urief among others, is a medication used for the symptomatic treatment of benign prostatic hyperplasia. It acts as an alpha-1 adrenergic receptor antagonist.

In the Vinony graph

Within Vinony's link graph, silodosin is referenced by 603 other articles, and connects out to propranolol, levonordefrin and 2C-G.

It sits within the topics Alpha-1 blockers, Benzamides and Drugboxes which contain changes to verified fields.

Its subject is documented across 18 Wikipedia language editions.

Key facts

Drug.MedlinePlus: a609002
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 464390579
Drug.image: Silodosin Structural Formula V.1.svg
Drug.image_class: skin-invert-image
Drug.tradename: Urief, others
Drug.routes_of_administration: By mouth
Drug.class: α1 blocker
Drug.ATC_prefix: G04
Drug.ATC_suffix: CA04
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.legal_status: Rx-only
Drug.bioavailability: 32%
Drug.protein_bound: 96.6%

via Wikipedia infobox

Research

587 papers

Silodosin.2012
Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology.Advances in therapy · 2019
Does Silodosin Improve Primary Ureteroscopy Access and Outcomes: Meta-Analysis of Randomized Controlled Trials.Journal of endourology · 2024
Focus on Silodosin: Pros and Cons of Uroselectivity.Research and reports in urology · 2020
Silodosin as a medical expulsive therapy for distal ureteral stones: A systematic review and meta-analysis.Indian journal of urology : IJU : journal of the Urological Society of India · 2023

via PubMed

Wikidata facts

Mass: 495.234491

Show 5 more facts

Commons category: Silodosin
chemical formula: C₂₅H₃₂F₃N₃O₄
isomeric SMILES: C[C@H](CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
canonical SMILES: CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
defined daily dose: 8

Sources (5)

via Wikidata · CC0

~8 min read

Encyclopedic overview

13 sections

Contents

Medical uses
Contraindications
Side effects
Interactions
Pharmacology
Mechanism of action
Pharmacokinetics
History
Society and culture
Brand names
Research
References
Further reading

{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464390579 | image = Silodosin Structural Formula V.1.svg | image_class = skin-invert-image | width = | alt = | caption =

Excerpted from Wikipedia’s “silodosin” article, available under the CC BY-SA 4.0 licence.