-Midodrin%20Structural%20Formula%20V1.svg)
midodrine
Sign in to saveAlso known as A-4020 Linz, Proamatine®, ST-1085, DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid, 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide, 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol, (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
Midodrine, sold under the brand name Proamatine among others, is an antihypotensive medication used to treat orthostatic hypotension (low blood pressure when standing) and urinary incontinence. It is taken by mouth.
Key facts
- Drug.KEGG
- D08220
- Drug.ChEBI
- 6933
- Drug.ChEMBL
- 1201212
- Drug.image
- Midodrine structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.caption
- Above: molecular structure of midodrineBelow: 3D representation of midodrine
- Drug.image2
- Midodrine 3D.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.tradename
- Proamatine, others
- Drug.MedlinePlus
- a616030
- Drug.DailyMedID
- Midodrine
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.class
- α1-Adrenergic receptor agonist; Antihypotensive agent
- Drug.ATC_prefix
- C01
- Drug.ATC_suffix
- CA17
via Wikipedia infobox
Research
990 papers- Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial.Intensive care medicine · 2020
- Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
- Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial.Hepatology (Baltimore, Md.) · 2015
- Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial.Pharmacotherapy · 2025
- Midodrine for severe orthostatic hypotension.Drug and therapeutics bulletin · 2016
via PubMed
Wikidata facts
- Mass
- 254.126657
Show 5 more facts
- chemical formula
- C₁₂H₁₈N₂O₄
- canonical SMILES
- COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
- World Health Organisation international non-proprietary name
- midodrine
- defined daily dose
- 30
- Commons category
- Midodrine
via Wikidata · CC0
~7 min read
Article
16 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Stereochemistry
- Synthesis
- History
- Society and culture
- Names
- See also
- References
- External links
Midodrine, sold under the brand name Proamatine among others, is an antihypotensive medication used to treat orthostatic hypotension (low blood pressure when standing) and urinary incontinence. It is taken by mouth.
Side effects of midodrine include hypertension (high blood pressure), paresthesia, itching (pruritus), goose bumps, chills, urinary urgency, urinary retention, and urinary frequency. Midodrine is a prodrug of its active metabolite desglymidodrine. This metabolite acts as a selective agonist of the α1-adrenergic receptor. This in turn results in vasoconstriction and increased blood pressure.