dopexamine
Sign in to saveDopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine.
Research
369 papers- Dopexamine after cardiac surgery.Drug and therapeutics bulletin · 1995
- [Dopexamine: a new dopaminergic agonist].Annales francaises d'anesthesie et de reanimation · 1993
- Dopexamine and its role in the protection of hepatosplanchnic and renal perfusion in high-risk surgical and critically ill patients.British journal of anaesthesia · 2005
- Dopexamine: much more than a vasoactive agent.Critical care medicine · 1998
- Dopexamine hydrochloride. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in acute cardiac insufficiency.Drugs · 1990
via PubMed
Wikidata facts
- Mass
- 356.246
Show 3 more facts
- chemical formula
- C₂₂H₃₂N₂O₂
- canonical SMILES
- C1=CC=C(C=C1)CCNCCCCCCNCCC2=CC(=C(C=C2)O)O
- Commons category
- Dopexamine
Sources (2)
via Wikidata · CC0
~7 min read
Article
8 sectionsContents
- Medical use
- Adverse effects
- Pharmacology
- Mechanism of action
- Chemistry
- History
- Research
- References
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