Structure via PubChem · Public domain (PubChem)
پنتوکسی فیلین
Sign in to saveAlso known as BL-191, Trental®, Pentoxifyllin, Pentoxifyllinum, Pentoxifylline, Oxpentifylline, Pentoxifilina
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It was approved for medical use in 1984 and is available as generic and sold under many brand names worldwide like Trental.
Key facts
- Drug.pregnancy_AU
- B1
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464198476
- Drug.IUPAC_name
- 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione
- Drug.image
- Pentoxifylline.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 180
- Drug.image2
- Pentoxifylline xtal 2005 ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Trental, many other names worldwide
- Drug.MedlinePlus
- a685027
- Drug.licence_US
- Pentoxifylline
- Drug.pregnancy_US
- C
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C13H18N4O3
- Molecular weight
- 278.31 g/mol
- IUPAC name
- 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
- SMILES
- CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
- InChIKey
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N
- XLogP
- 0.3
- Polar surface area
- 75.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1984
- Admin. routes
- oral
- Indications
- chronic kidney disease, non-small cell lung carcinoma, cutaneous Leishmaniasis, endometriosis
via ChEMBL · EBI
Research
6,081 papers- Pentoxifylline in dermatology.Journal of cosmetic dermatology · 2023
- Pentoxifylline for intermittent claudication.The Cochrane database of systematic reviews · 2020
- Pentoxifylline.Journal of the American Academy of Dermatology · 1994
- Pentoxifylline review.Journal of the American Podiatric Medical Association · 1987
- Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients.Pharmacology research & perspectives · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 278.138
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₃H₁₈N₄O₃
- medical condition treated
- intermittent claudication
- Commons category
- Pentoxifylline
- canonical SMILES
- CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
- route of administration
- oral administration
- half-life
- 0.6
- has characteristic
- bitterness
- stylized name
- TRENtal
Sources (6)
via Wikidata · CC0