ZHX1
Sign in to saveAlso known as zinc fingers and homeoboxes 1
Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.
Gene data
ZHX1- Name
- zinc fingers and homeoboxes 1
- Type
- protein-coding
- Position
- 123,246,669–123,275,541 (−)
- Ensembl
- ENSG00000165156
- RefSeq RNA
- NM_001017926.3, NM_007222.5, NR_037873.2, NR_037874.2
- RefSeq protein
- NP_001017926.1, NP_009153.3
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
zinc fingers and homeoboxes 1
- Symbol
- ZHX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:123,246,669-123,275,541
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ZHX1 PDB 2ecb.png
Show 7 more facts
- HomoloGene ID
- 5225
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11244
- genomic end
- 124287781
- genomic start
- 124260696
- chromosome
- human chromosome 8
- cytogenetic location
- 8q24.13
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.
Excerpted from Wikipedia’s “ZHX1” article, available under the CC BY-SA 4.0 licence.