NFYA

Also known as CBF-A, CBF-B, HAP2, NF-YA, nuclear transcription factor Y subunit alpha

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.

In the Vinony graph

Within Vinony's link graph, NFYA is referenced by 820 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 6 and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

NFYA

Name: nuclear transcription factor Y subunit alpha
Type: protein-coding
Position: 41,072,040–41,103,063 (+)
Aliases: CBF-A, CBF-B, HAP2, NF-YA
Ensembl: ENSG00000001167
RefSeq RNA: NM_002505.5, NM_021705.4
RefSeq protein: NP_002496.1, NP_068351.1

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm CCAAT-binding factor complex CCAAT-binding factor complex

Pathways

Antigen processing and presentation - Homo sapiens (human)Spinocerebellar ataxia - Homo sapiens (human)Tuberculosis - Homo sapiens (human)Metabolism Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Regulation of cholesterol biosynthesis by SREBP (SREBF)PPARA activates gene expression Generic Transcription Pathway Cellular responses to stress

via MyGene.info

Gene · Ensembl

nuclear transcription factor Y subunit alpha

Symbol: NFYA
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:41,072,040-41,103,063
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 32114
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4800
genomic end: 41102403
genomic start: 41072974
expressed in: monocyte
chromosome: human chromosome 6
cytogenetic location: 6p21.1

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Interactions
Structure
References
Further reading
External links

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.

== Function == The protein encoded by this gene is one subunit of a trimeric complex NF-Y, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit NFYA associates with a tight dimer composed of the NFYB and NFYC subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the NFYA subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Excerpted from Wikipedia’s “NFYA” article, available under the CC BY-SA 4.0 licence.