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GeneQ18030127· pop 6· linked from 815 articles

NFYC

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Also known as CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC, nuclear transcription factor Y subunit gamma

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

In the Vinony graph

Within Vinony's link graph, NFYC is referenced by 815 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 1 and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

NFYC

Name: nuclear transcription factor Y subunit gamma
Type: protein-coding
Position: 40,691,570–40,771,606 (+)
Aliases: CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC
Ensembl: ENSG00000066136
RefSeq RNA: NM_001142587.2, NM_001142588.2, NM_001142589.2, NM_001142590.2, NM_001308114.1
RefSeq protein: NP_001136059.1, NP_001136060.1, NP_001136061.1, NP_001136062.1, NP_001295043.1

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II protein folding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex CCAAT-binding factor complex

Pathways

Antigen processing and presentation - Homo sapiens (human)Tuberculosis - Homo sapiens (human)Metabolism Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Regulation of cholesterol biosynthesis by SREBP (SREBF)PPARA activates gene expression Generic Transcription Pathway Cellular responses to stress Cellular responses to stress

via MyGene.info

Gene · Ensembl

nuclear transcription factor Y subunit gamma

Symbol: NFYC
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:40,691,570-40,771,606
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NFYC PDB 1n1j.png

Show 7 more facts

HomoloGene ID: 7440
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4802
genomic start: 41157320
chromosome: human chromosome 1
genomic end: 41237275
cytogenetic location: 1p34.2

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

== Function ==

Excerpted from Wikipedia’s “NFYC” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1 Transcription factors