Structure via PubChem · Public domain (PubChem)
4-hydroxy-TEMPO
Sign in to saveAlso known as Tempol, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxyl, tempol
4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable aminoxyl radical. Its major appeal over TEMPO is that it is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.
In the Vinony graph
Within Vinony's link graph, 4-hydroxy-TEMPO is referenced by 8 other articles, and connects out to ammonia, digital object identifier and chemical formula.
Vinony files it under Amine oxides, Chembox having GHS data and Chembox image size set.
Its subject is documented across 10 Wikipedia language editions.
Chemical data
- Formula
- C9H18NO2
- Molecular weight
- 172.24 g/mol
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, anus cancer, COVID-19, glioblastoma multiforme
via ChEMBL · EBI
Research
142 papers- Nitroxide Hormesis in Yeast: 4-Hydroxy-TEMPO Modulates Aging, and Cell Cycle.Molecules (Basel, Switzerland) · 2026
- 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis.ACS chemical neuroscience · 2014
- Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1.Drug and chemical toxicology · 2022
- Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO in aqueous solution.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2014
- 4-hydroxy tempo improves mitochondrial and neurobehavioral deficits in experimental model of Huntington's disease.Synapse (New York, N.Y.) · 2015
via PubMed
Wikidata facts
- Mass
- 172.134
Show 4 more facts
- canonical SMILES
- CC1(CC(CC(N1[O])(C)C)O)C
- chemical formula
- C₉H₁₈NO₂
- name in kana
- テンポル
- Commons category
- 4-Hydroxy-TEMPO
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable aminoxyl radical. Its major appeal over TEMPO is that it is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.
thumb|center|350px|Example synthesis of 4-Hydroxy-TEMPO from phorone, which is itself made from acetone and ammonia
Excerpted from Wikipedia’s “4-hydroxy-TEMPO” article, available under the CC BY-SA 4.0 licence.