acylation
Sign in to saveIn chemistry, acylation is a broad class of chemical reactions in which an acyl group () is added to a substrate. The compound providing the acyl group is called the acylating agent. The substrate to be acylated and the product include the following: alcohols, esters amines, amides arenes or alkenes, ketones A particularly common type of acylation is acetylation, the addition of the acetyl group. Closely related to acylation is formylation, which employ sources of "HCO+ in place of "RCO+".
Research
52,079 papers- Protein acylation: mechanisms, biological functions and therapeutic targets.Signal transduction and targeted therapy · 2022
- Post-translational acylation of proteins in cardiac hypertrophy.Nature reviews. Cardiology · 2025
- Histone acylation at a glance.Journal of cell science · 2024
- Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification.Journal of experimental & clinical cancer research : CR · 2022
- S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes.Nature metabolism · 2024
via PubMed
~2 min read
Article
4 sectionsContents
- Examples
- Acylation in biology
- See also
- References
In chemistry, acylation is a broad class of chemical reactions in which an acyl group () is added to a substrate. The compound providing the acyl group is called the acylating agent. The substrate to be acylated and the product include the following: alcohols, esters amines, amides arenes or alkenes, ketones A particularly common type of acylation is acetylation, the addition of the acetyl group. Closely related to acylation is formylation, which employ sources of "HCO+ in place of "RCO+".
==Examples== Because they form a strong electrophile when treated with Lewis acids, acyl halides are commonly used as acylating agents. For example, Friedel–Crafts acylation uses acetyl chloride () as the agent and aluminum chloride () as a catalyst to add an acetyl group to benzene: