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adapromine
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Adapromine is an antiviral drug of the adamantane group related to amantadine (1-aminoadamantane), rimantadine (1-(1-aminoethyl)adamantane), and memantine (1-amino-3,5-dimethyladamantane) that is marketed in Russia for the treatment and prevention of influenza. It is an alkyl analogue of rimantadine and is similar to rimantadine in its antiviral activity but possesses a broader spectrum of action, being effective against influenza viruses of both type A and B. Strains of type A influenza virus with resistance to adapromine and rimantadine and the related drug deitiforine were encountered in Mo
Chemical data
- Formula
- C13H23N
- Molecular weight
- 193.33 g/mol
- IUPAC name
- 1-(1-adamantyl)propan-1-amine
- SMILES
- CCC(C12CC3CC(C1)CC(C3)C2)N
- InChIKey
- RKPSOUZGYPZAHW-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 26 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 193.18305
Show 3 more facts
- Commons category
- Adapromine
- canonical SMILES
- CCC(C12CC3CC(C1)CC(C3)C2)N
- chemical formula
- C₁₃H₂₃N
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Adapromine is an antiviral drug of the adamantane group related to amantadine (1-aminoadamantane), rimantadine (1-(1-aminoethyl)adamantane), and memantine (1-amino-3,5-dimethyladamantane) that is marketed in Russia for the treatment and prevention of influenza. It is an alkyl analogue of rimantadine and is similar to rimantadine in its antiviral activity but possesses a broader spectrum of action, being effective against influenza viruses of both type A and B. Strains of type A influenza virus with resistance to adapromine and rimantadine and the related drug deitiforine were encountered in Mongolia and the Soviet Union in the 1980s.
Electroencephalography (EEG) studies of animals suggest that adapromine and related adamantanes including amantadine, bromantane (1-amino-2-bromophenyladamantane), and memantine have psychostimulant-like and possibly antidepressant-like effects, and that these effects may be mediated via catecholaminergic processes. These psychostimulant effects differ qualitatively from those of conventional psychostimulants like amphetamine however, and the adamantane derivatives have been described contrarily as "adaptogens" and as "actoprotectors".
Excerpted from Wikipedia’s “adapromine” article, available under the CC BY-SA 4.0 licence.
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