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almorexant
Sign in to saveAlso known as ACT-078573
Almorexant (INN), also known by its development code ACT-078573, is an orexin antagonist, acting as a competitive antagonist of the OX1 and OX2 orexin receptors, which was being developed by the pharmaceutical companies Actelion and GSK for the treatment of insomnia. Development of the drug was abandoned in January 2011 due to concerns over the hepatic safety of almorexant after transient increases in liver enzymes were observed in trials.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 512.228678
Show 3 more facts
- chemical formula
- C₂₉H₃₁F₃N₂O₃
- isomeric SMILES
- CNC(=O)[C@@H](C1=CC=CC=C1)N2CCC3=CC(=C(C=C3[C@@H]2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC
- canonical SMILES
- CNC(=O)C(C1=CC=CC=C1)N2CCC3=CC(=C(C=C3C2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
5 sectionsContents
- Pharmacology
- Pharmacodynamics
- History
- References
- External links
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477318417 | IUPAC_name = (2R)-2-[(1S)- 6,7-Dimethoxy-1-{2-[4-(trifluoromethyl)phenyl]ethyl}-3,4-dihydroisoquinolin-2(1H)-yl]-N-methyl-2-phenylacetamide | image = Almorexant.svg | image_class = skin-invert-image | width = 200px
| tradename = | routes_of_administration = By mouth | class = Orexin antagonist
Excerpted from Wikipedia’s “almorexant” article, available under the CC BY-SA 4.0 licence.