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AM-694
Sign in to saveAM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
Chemical data
- Formula
- C20H19FINO
- Molecular weight
- 435.3 g/mol
- IUPAC name
- [1-(5-fluoropentyl)indol-3-yl]-(2-iodophenyl)methanone
- SMILES
- C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)C3=CC=CC=C3I
- InChIKey
- LFFIIZFINPPEMC-UHFFFAOYSA-N
- XLogP
- 5.3
- Polar surface area
- 22 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 435.05
Show 2 more facts
- canonical SMILES
- C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)C3=CC=CC=C3I
- chemical formula
- C₂₀H₁₉FINO
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Pharmacology
- Metabolism
- Legal status
- Finland
- See also
- References
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
==Pharmacology== AM-694 is an agonist for cannabinoid receptors. It has a Ki of 0.08 nM at CB1 and 18 times selectivity over CB2 with a Ki of 1.44 nM. It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the 18F radiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.
Excerpted from Wikipedia’s “AM-694” article, available under the CC BY-SA 4.0 licence.