Structure via PubChem · Public domain (PubChem)
amperozide
Sign in to saveAmperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity. ==See also== FG-5893 == References ==
Chemical data
- Formula
- C23H29F2N3O
- Molecular weight
- 401.5 g/mol
- IUPAC name
- 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
- SMILES
- CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
- InChIKey
- NNAIYOXJNVGUOM-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 35.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 401.227869
Show 4 more facts
- canonical SMILES
- CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
- chemical formula
- C₂₃H₂₉F₂N₃O
- subject has role
- serotonin antagonist
- Commons category
- Amperozide
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity. ==See also== FG-5893 == References ==
Category:5-HT2A antagonists Category:Piperazines Category:Ureas Category:4-Fluorophenyl compounds
Excerpted from Wikipedia’s “amperozide” article, available under the CC BY-SA 4.0 licence.