anguish

thumb|262px|"Hours of anguish" (Julio Romero de Torres, 1904).

Anguish (from the Latin angustia "distress") is "extreme unhappiness caused by physical or mental suffering." The feeling of anguish is typically preceded by a tragedy or event that has a profound meaning to the being in question. Anguish can be felt physically or mentally (often referred to as emotional distress).