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arterolane
Sign in to saveAlso known as OZ277, RBx 11160, RBX11160
Arterolane, also known as OZ277 or RBx 11160, is an antimalarial compound marketed by Ranbaxy Laboratories. It was discovered by US and European scientists coordinated by the Medicines for Malaria Venture (MMV). Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide (trioxolane) group and an adamantane substituent.
Chemical data
- Formula
- C22H36N2O4
- Molecular weight
- 392.5 g/mol
- SMILES
- CC(C)(CNC(=O)CC1CCC2(CC1)OC3(C4CC5CC(C4)CC3C5)OO2)N
- InChIKey
- VXYZBLXGCYNIHP-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 82.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Has use
- medication
Show 2 more facts
- chemical formula
- C₂₂H₃₆N₂O₄
- Commons category
- Arterolane
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Arterolane, also known as OZ277 or RBx 11160, is an antimalarial compound marketed by Ranbaxy Laboratories. It was discovered by US and European scientists coordinated by the Medicines for Malaria Venture (MMV). Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide (trioxolane) group and an adamantane substituent.
Initial results were disappointing, and in 2007 MMV withdrew support, after having invested $20M in the research; Ranbaxy said at the time that it intended to continue developing arterolane in combination with another drug. In 2009, Ranbaxy started a Phase II clinical trial of arterolane in combination with piperaquine, and it was published in 2015.
Excerpted from Wikipedia’s “arterolane” article, available under the CC BY-SA 4.0 licence.