Structure via PubChem · Public domain (PubChem)
bazedoxifene
Sign in to saveAlso known as Conbriza®, TSE-424, Viviant®, WAY-140424, bazedoxifene/conjugated estrogens
Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM). Since late 2013 it has had U.S. FDA approval for bazedoxifene as part of the combination drug Duavee in the prevention (not treatment) of postmenopausal osteoporosis. It is also being studied for possible treatment of breast cancer and pancreatic cancer.
Chemical data
- Formula
- C30H34N2O3
- Molecular weight
- 470.6 g/mol
- IUPAC name
- 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol
- SMILES
- CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O
- InChIKey
- UCJGJABZCDBEDK-UHFFFAOYSA-N
- XLogP
- 6.1
- Polar surface area
- 57.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2009
- Admin. routes
- oral
- Indications
- postmenopausal osteoporosis, osteoporosis, breast ductal carcinoma in situ, breast cancer
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 470.257
- Has use
- medication
Show 7 more facts
- chemical formula
- C₃₀H₃₄N₂O₃
- canonical SMILES
- CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O
- defined daily dose
- 20
- subject has role
- selective estrogen-receptor modulators
- significant drug interaction
- phenytoin
- Commons category
- Bazedoxifene
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~3 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Available forms
- Pharmacology
- Pharmacodynamics
- Chemistry
- History
- Approval
- Society and culture
- Brand names
- See also
- References
Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM). Since late 2013 it has had U.S. FDA approval for bazedoxifene as part of the combination drug Duavee in the prevention (not treatment) of postmenopausal osteoporosis. It is also being studied for possible treatment of breast cancer and pancreatic cancer.
==Medical uses== Bazedoxifene is used in the prevention of postmenopausal osteoporosis.
Excerpted from Wikipedia’s “bazedoxifene” article, available under the CC BY-SA 4.0 licence.
Available in 14 languages
via Wikidata sitelinks · CC0