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Structure via PubChem · Public domain (PubChem)
belotecan
Sign in to saveBelotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for small-cell lung cancer and ovarian cancer, approved in South Korea under the trade name Camtobell, presented in 2 mg vials for injection. The drug has been marketed by Chong Kun Dang Pharmaceuticals since 2003.
Chemical data
- Formula
- C25H27N3O4
- Molecular weight
- 433.5 g/mol
- IUPAC name
- (19S)-19-ethyl-19-hydroxy-10-[2-(propan-2-ylamino)ethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
- SMILES
- CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O
- InChIKey
- LNHWXBUNXOXMRL-VWLOTQADSA-N
- XLogP
- 1.6
- Polar surface area
- 91.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- small cell lung carcinoma, non-small cell lung carcinoma, neoplasm, cervical cancer
via ChEMBL · EBI
Research
88 papers- Preclinical profiles of SKB264, a novel anti-TROP2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132.Frontiers in oncology · 2022
- Results of a phase 1/2 study of sacituzumab tirumotecan in patients with unresectable locally advanced or metastatic solid tumors refractory to standard therapies.Journal of hematology & oncology · 2025
- Belotecan, new camptothecin analogue, is active in patients with small-cell lung cancer: results of a multicenter early phase II study.Annals of oncology : official journal of the European Society for Medical Oncology · 2008
- Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial.BMC cancer · 2016
- A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer.British journal of cancer · 2021
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 433.2
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₅H₂₇N₃O₄
- isomeric SMILES
- CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O
- canonical SMILES
- CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O
- Commons category
- Belotecan
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Mechanism of action
- References
Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for small-cell lung cancer and ovarian cancer, approved in South Korea under the trade name Camtobell, presented in 2 mg vials for injection. The drug has been marketed by Chong Kun Dang Pharmaceuticals since 2003.
==Mechanism of action== Belotecan blocks topoisomerase I with a pIC50 of 6.56, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.
Excerpted from Wikipedia’s “belotecan” article, available under the CC BY-SA 4.0 licence.