bombesin

Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina)

Research

5,610 papers

Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology.Current opinion in endocrinology, diabetes, and obesity · 2015
Bombesin receptor antagonists.Critical reviews in oncology/hematology · 1996
Bombesin and its family of peptides: prospects for the treatment of obesity.European journal of pharmacology · 2002
Bombesin-like peptides and cancer.Critical reviews in oncology/hematology · 1996
Bombesin and the brain-gut axis.Peptides · 2000

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Wikidata facts

Mass: 1618.8150636799987

Show 4 more facts

isomeric SMILES: C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]4CCC(=O)N4
chemical formula: C₇₁H₁₁₀N₂₄O₁₈S
subject has role: neurotransmitter
canonical SMILES: CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(C)C)C(N)=O

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Encyclopedic overview

4 sections

Contents

Receptors
Effects
See also
References

Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina) by Vittorio Erspamer et al. and named after its source. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.

Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.

Excerpted from Wikipedia’s “bombesin” article, available under the CC BY-SA 4.0 licence.

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