cardiolipin
Sign in to saveCardiolipin (IUPAC name '1,3-bis(sn-3’-phosphatidyl)-sn-glycerol', "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn. In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it
In the Vinony graph
Within Vinony's link graph, cardiolipin is referenced by 158 other articles, and connects out to cytochrome c oxidase, glycerophospholipid and bacteria.
It sits within the topics Chemical articles without CAS registry number, Chemical pages without ChemSpiderID and Chemicals without a PubChem CID.
Its subject is documented across 20 Wikipedia language editions.
Research
10,438 papers- Cardiolipin, Non-Bilayer Structures and Mitochondrial Bioenergetics: Relevance to Cardiovascular Disease.Cells · 2021
- Mammalian cardiolipin biosynthesis.Chemistry and physics of lipids · 2014
- Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1.Nature communications · 2025
- Role of cardiolipin in skeletal muscle function and its therapeutic implications.Cell communication and signaling : CCS · 2025
- Cardiolipin metabolism and Barth Syndrome.Progress in lipid research · 2006
via PubMed
Wikidata facts
- Has part
- carbon
Show 2 more facts
- isomeric SMILES
- OC(COP(O)(=O)OC[C@@H](COC([*])=O)OC([*])=O)COP(O)(=O)OC[C@@H](COC([*])=O)OC([*])=O
- Commons category
- Cardiolipins
Sources (2)
via Wikidata · CC0
~15 min read
Encyclopedic overview
30 sectionsContents
- Structure
- Methods to quantify and detect cardiolipin
- Metabolism and catabolism
- Metabolism
- Eukaryotic pathway
- Prokaryotic pathway
- Catabolism
- Functions
- Regulates aggregate structures
- Facilitates the quaternary structure
- Triggers apoptosis
- Serves as proton trap for oxidative phosphorylation
- Other functions
- Clinical significance
- Metabolic diseases
- Barth syndrome
- Combined malonic and methylmalonic aciduria (CMAMMA)
- Tangier disease
- Parkinson's disease and Alzheimer's disease
- Nonalcoholic fatty liver disease and heart failure
- Diabetes
- Syphilis
- HIV-1
- Cancer
- Antiphospholipid syndrome
- Additional anti-cardiolipin diseases
- Chronic fatigue syndrome
- See also
- References
- External links
Cardiolipin (IUPAC name '1,3-bis(sn-3’-phosphatidyl)-sn-glycerol', "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn. In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism.
== Structure == Cardiolipin in animal tissues|right|thumb|360px
Excerpted from Wikipedia’s “cardiolipin” article, available under the CC BY-SA 4.0 licence.