Structure via PubChem · Public domain (PubChem)
carfentanil
Sign in to saveAlso known as carfentanyl, methyl 1-fenylethyl-4-(N-fenylpropionamido)isonipecotaat, methyl 4-(N-propionyl-N-fenylamino)-1-(2-fenylethyl)-4-piperidine-carboxylaat, methyl 4-[N-(1-oxopropyl)-N-fenylamino]-1-(2-fenylethyl)-4-piperidinecarboxylaat, 4-[(1-oxopropyl)fenylamino]-1-(2-fenylethyl)-4-piperidinecarbonzuurmethylester
Carfentanil or carfentanyl, formerly sold under the brand name Wildnil, is an extremely potent opioid analgesic used in veterinary medicine to anesthetize large animals such as elephants and rhinoceroses. It is a structural analogue of the synthetic opioid analgesic fentanyl. It is typically administered in this context by tranquilizer dart. Carfentanil has also been used in humans to image opioid receptors. It has additionally been used as a recreational drug, typically by injection, insufflation, or inhalation. Deaths have been reported in association with carfentanil.
Chemical data
- Formula
- C24H30N2O3
- Molecular weight
- 394.5 g/mol
- IUPAC name
- methyl 1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxylate
- SMILES
- CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CC=C3)C(=O)OC
- InChIKey
- YDSDEBIZUNNPOB-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 49.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
548 papers- Carfentanil - from an animal anesthetic to a deadly illicit drug.Forensic science international · 2021
- Carfentanil: a weapon of mass destruction.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019
- DARK Classics in Chemical Neuroscience: Carfentanil.ACS chemical neuroscience · 2020
- Carfentanil: a narrative review of its pharmacology and public health concerns.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019
- Combative Treatment for Carfentanil Epidemic.Journal of addictions nursing · 2019
via PubMed
~8 min read
Encyclopedic overview
14 sectionsContents
- Uses
- Veterinary use
- Clinical use
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Increase in illicit use
- Seizures by authorities
- Moscow theater hostage crisis
- Potential as a chemical weapon
- Legal status
- See also
- References
Carfentanil or carfentanyl, formerly sold under the brand name Wildnil, is an extremely potent opioid analgesic used in veterinary medicine to anesthetize large animals such as elephants and rhinoceroses. It is a structural analogue of the synthetic opioid analgesic fentanyl. It is typically administered in this context by tranquilizer dart. Carfentanil has also been used in humans to image opioid receptors. It has additionally been used as a recreational drug, typically by injection, insufflation, or inhalation. Deaths have been reported in association with carfentanil.
Effects and side effects of carfentanil in humans are similar to those of other opioids and include euphoria, relaxation, pain relief, pupil constriction, drowsiness, sedation, slowed heart rate, low blood pressure, lowered body temperature, loss of consciousness, and suppression of breathing. The effects of carfentanil, including overdose, can be reversed by the opioid antagonists naloxone and naltrexone, though higher doses than usual may be necessary compared to other opioids. It acts as an ultrapotent and highly selective agonist of the μ-opioid receptor.
Excerpted from Wikipedia’s “carfentanil” article, available under the CC BY-SA 4.0 licence.