CDC34

Also known as E2-CDC34, UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.

Gene data

CDC34

Name: cell division cycle 34, ubiquitin conjugating enzyme
Type: protein-coding
Aliases: E2-CDC34, UBC3, UBCH3, UBE2R1

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cell division cycle 34, ubiquitin conjugating enzyme

Symbol: CDC34
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:531,435-542,092
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CDC34 PDB 2ob4.png

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HomoloGene ID: 55815
exact match: identifiers.org/ncbigene/997
genomic end: 542097
genomic start: 531760
cytogenetic location: 19p13.3

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CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle. Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1 - for ubiquitin-mediated protein degradation. CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.