cefditoren
Sign in to saveAlso known as CDTR-PI, Cefditoren Pivoxil, Cefditoren Pivaloyloxymethyl Ester
Research
345 papers- Cefditoren: a clinical overview.The new microbiologica · 2023
- Cefditoren.2006
- Cefditoren-induced hepatitis.Revista espanola de enfermedades digestivas · 2022
- Cefditoren pivoxil.Drugs · 2002
- [Cefditoren: a reality for the treatment of community infections].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2017
via PubMed
Wikidata facts
- Mass
- 506.050081
Show 5 more facts
- chemical formula
- C₁₉H₁₈N₆O₅S₃
- isomeric SMILES
- CC1=C(SC=N1)/C=C\C2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O
- canonical SMILES
- CC1=C(SC=N1)C=CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
- World Health Organisation international non-proprietary name
- cefditoren
- defined daily dose
- 0.4
Sources (3)
via Wikidata · CC0
~11 min read
Article
24 sectionsContents
- Structure
- Antimicrobial activity
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism and Excretion
- Medical uses
- Spectrum of bacterial susceptibility
- Dosage and administration
- Adults and Adolescents (≥12 Years)
- Children (2 months to 12 years of age)
- Pregnancy
- Pregnancy Category B
- Geriatric use
- International approvals
- Proprietary Preparations and Countries
- Contraindications
- Safety and tolerability
- Guidelines
- Japanese Guidelines
- A panel of 70 pulmonologists, coordinated by 9 experts in respiratory care recommendations
- Ideal for switch therapy
- References
- External links
Cefditoren, also known as cefditoren pivoxil is an antibiotic used to treat infections caused by Gram-positive and Gram-negative bacteria that are resistant to other antibiotics. It is mainly used for treatment of community acquired pneumonia. It is taken by mouth and is in the cephalosporin family of antibiotics, which is part of the broader beta-lactam group of antibiotics.
== Structure == Like other cephalosporins, cefditoren has a β-lactam ring at the 7 position of cephalosporin ring that is responsible for its inhibitory action on bacterial cell wall synthesis. In addition to the cephem nucleus common to all cephalosporins, cefditoren has an aminothiazole group that enhances its activity against Gram-negative organisms, a methylthiazole group that enhances its activity against Gram-positive organisms, a methoxyimino group that gives it stability against β-lactamases, and a pivoxil ester group that enhances oral bioavailability.