cephalothin
Also known as cefalotin sodium, Keflin®, CET, 7-(2'-thienylacetamido)cephalosporanic acid, Cefalotin, 7-(Thiophene-2-acetamido)cephalosporin, Cefalotina
Cefalotin (INN) or cephalothin (USAN) is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. It was the first cephalosporin marketed (1964) and continues to be widely used. Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.
Chemical data
- Formula
- C16H16N2O6S2
- Molecular weight
- 396.4 g/mol
- IUPAC name
- (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- SMILES
- CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)O
- InChIKey
- XIURVHNZVLADCM-IUODEOHRSA-N
- XLogP
- -0.4
- Polar surface area
- 167 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
4,740 papersArticle
1 sectionsContents
- References
Cefalotin (INN) or cephalothin (USAN) is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. It was the first cephalosporin marketed (1964) and continues to be widely used. Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.
It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agents cefalexin and cefadroxil. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.