Structure via PubChem · Public domain (PubChem)
cinanserin
Sign in to saveCinanserin (; developmental code name SQ-10643) is a serotonin 5-HT2A and 5-HT2C receptor antagonist which was discovered in the 1960s and was never marketed. It has about 50-fold higher affinity for the 5-HT2A receptor than for 5-HT2C, and very low affinity for 5-HT1 receptors. The drug also inhibits the 3C-like protease of SARS-CoV-1 and SARS-CoV-2, but with much lower affinity.
Chemical data
- Formula
- C20H24N2OS
- Molecular weight
- 340.5 g/mol
- IUPAC name
- (E)-N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenylprop-2-enamide
- SMILES
- CN(C)CCCSC1=CC=CC=C1NC(=O)/C=C/C2=CC=CC=C2
- InChIKey
- RSUVYMGADVXGOU-BUHFOSPRSA-N
- XLogP
- 4.1
- Polar surface area
- 57.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 340.161
Show 4 more facts
- chemical formula
- C₂₀H₂₄N₂OS
- subject has role
- serotonin antagonist
- canonical SMILES
- CN(C)CCCSC1=CC=CC=C1NC(=O)C=CC2=CC=CC=C2
- isomeric SMILES
- CN(C)CCCSC1=CC=CC=C1NC(=O)/C=C/C2=CC=CC=C2
Sources (1)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 449572536 | image = Cinanserin.svg | image_class = skin-invert-image | width = 250px
| tradename = | pregnancy_category = | legal_status = | routes_of_administration = | class = Serotonin 5-HT2 receptor antagonist; Serotonin 5-HT2A receptor antagonist | ATC_prefix = None | ATC_suffix =
Excerpted from Wikipedia’s “cinanserin” article, available under the CC BY-SA 4.0 licence.