CLDN11
Sign in to saveAlso known as OSP, OTM, claudin 11, HLD22
Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.
In the Vinony graph
Within Vinony's link graph, CLDN11 is referenced by 3 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CLDN11- Name
- claudin 11
- Type
- protein-coding
- Position
- 170,418,864–170,454,733 (+)
- Aliases
- HLD22, OSP, OTM
- Ensembl
- ENSG00000013297
- RefSeq RNA
- NM_001185056.2, NM_005602.6
- RefSeq protein
- NP_001171985.1, NP_005593.2
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
claudin 11
- Symbol
- CLDN11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:170,418,864-170,454,733
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4093
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5010
- genomic start
- 170418868
- chromosome
- human chromosome 3
- genomic end
- 170454733
- cytogenetic location
- 3q26.2
- expressed in
- pars compacta
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.
== Function ==
Excerpted from Wikipedia’s “CLDN11” article, available under the CC BY-SA 4.0 licence.