CLEC5A

Also known as CLECSF5, MDL-1, MDL1, C-type lectin domain family 5 member A, C-type lectin domain containing 5A

C-type lectin domain family 5 member A (CLEC5A), also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL-1) is a C-type lectin that in humans is encoded by the CLEC5A gene.

Gene data

CLEC5A

Name: C-type lectin domain containing 5A
Type: protein-coding
Position: 141,927,357–141,947,007 (−)
Aliases: CLECSF5, MDL-1, MDL1
Ensembl: ENSG00000258227
RefSeq RNA: NM_001301167.2, NM_013252.3, XM_011515995.3, XM_054357726.1, XR_007059995.1
RefSeq protein: NP_001288096.1, NP_037384.1, XP_011514297.1, XP_054213701.1

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

positive regulation of cytokine production osteoblast development osteoblast development cellular defense response signal transduction negative regulation of apoptotic process negative regulation of apoptotic process innate immune response

Molecular function

virus receptor activity virus receptor activity virus receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane cell surface cell surface specific granule membrane tertiary granule membrane

Pathways

Disease Innate Immune System Immune System DAP12 interactions Infectious disease Neutrophil degranulation Viral Infection Pathways Dengue Virus Infection Dengue Virus-Host Interactions Dengue virus activates/modulates innate and adaptive immune responses

via MyGene.info

Gene · Ensembl

C-type lectin domain containing 5A

Symbol: CLEC5A
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:141,927,357-141,947,007
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8302
exact match: identifiers.org/ncbigene/23601
genomic start: 141627157
genomic end: 141646807
cytogenetic location: 7q34

Sources (3)

via Wikidata · CC0

~3 min read

Article

5 sections

Contents

Viral pathology
Use in therapy
References
Further reading
External links

Structurally MDL-1 is a type II transmembrane protein with a short cytoplasmic tail and without signaling motifs, therefore it requires association with the adaptor protein DAP12 to generate signals via Syk pathway.