CLEC5A

Also known as CLECSF5, MDL-1, MDL1, C-type lectin domain family 5 member A, C-type lectin domain containing 5A

C-type lectin domain family 5 member A (CLEC5A), also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL-1) is a C-type lectin that in humans is encoded by the CLEC5A gene.

Gene data

CLEC5A

Name: C-type lectin domain containing 5A
Type: protein-coding
Position: 141,927,357–141,947,007 (−)
Aliases: CLECSF5, MDL-1, MDL1
Ensembl: ENSG00000258227
RefSeq RNA: NM_001301167.2, NM_013252.3, XM_011515995.3, XM_054357726.1, XR_007059995.1
RefSeq protein: NP_001288096.1, NP_037384.1, XP_011514297.1, XP_054213701.1

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

positive regulation of cytokine production

Article

5 sections

Contents

Viral pathology
Use in therapy
References
Further reading
External links

Structurally MDL-1 is a type II transmembrane protein with a short cytoplasmic tail and without signaling motifs, therefore it requires association with the adaptor protein DAP12 to generate signals via Syk pathway.