Structure via PubChem · Public domain (PubChem)
clentiazem
Sign in to saveClentiazem is a calcium channel blocker.
Chemical data
- Formula
- C22H25ClN2O4S
- Molecular weight
- 449 g/mol
- IUPAC name
- [(2S,3S)-8-chloro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
- SMILES
- CC(=O)O[C@@H]1[C@@H](SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
- InChIKey
- GYKFWCDBQAFCLJ-RTWAWAEBSA-N
- XLogP
- 3.7
- Polar surface area
- 84.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
94 papers- Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia.The Canadian journal of cardiology · 1995
- Metabolism of clentiazem in rats.Biological & pharmaceutical bulletin · 1993
- Clentiazem reduces infarct size in rabbit middle cerebral artery occlusion.Stroke · 1991
- Clentiazem protects against chronic cerebral vasospasm in rabbit basilar artery.Stroke · 1991
- Clentiazem, diltiazem, and cold cardioplegia in isolated ischemic rabbit hearts: relation between additive cardioprotection, physicochemical properties, and preservation of myocardial lipid components.Journal of cardiovascular pharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 448.122
Show 5 more facts
- chemical formula
- C₂₂H₂₅ClN₂O₄S
- isomeric SMILES
- CC(=O)O[C@@H]1[C@@H](SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
- canonical SMILES
- CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
- subject has role
- platelet aggregation inhibitors
- Commons category
- Clentiazem
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Clentiazem is a calcium channel blocker.
It is a chlorine derivative of diltiazem.
Excerpted from Wikipedia’s “clentiazem” article, available under the CC BY-SA 4.0 licence.