collagenase
Sign in to saveCollagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.
Key facts
- Protein.Name
- Matrix metallopeptidase 8 (neutrophil collagenase)
- Protein.HGNCid
- 7175
- Protein.Symbol
- MMP8
- Protein.EntrezGene
- 4317
- Protein.OMIM
- 120355
- Protein.RefSeq
- NM_002424
- Protein.UniProt
- P22894
- Protein.ECnumber
- 3.4.24.3 Chromosome = 11
- Protein.Chromosome
- 11
- Protein.Arm
- q
- Protein.Band
- 21
- Protein.LocusSupplementaryData
- -q22
- Protein family.Name
- Peptidase M9
- Protein family.Symbol
- Peptidase M9
- Protein family.Pfam
- PF01752
- Protein family.Pfam_clan
- CL0126
- Protein family.InterPro
- IPR013510
- Protein family.MEROPS
- M9
via Wikipedia infobox
Research
63,421 papers- Collagenase Injection versus Limited Fasciectomy for Dupuytren's Contracture.The New England journal of medicine · 2024
- Collagenase Clostridium Histolyticum: A Review in Peyronie's Disease.Clinical drug investigation · 2020
- Degradation Therapy with Collagenase and Deoxycholate.Facial plastic surgery clinics of North America · 2023
- Collagenase-producing bacteria are common in anastomotic leakage after colorectal surgery: a systematic review.International journal of colorectal disease · 2023
- Collagenase-Induced Osteoarthritis in Mice.Methods in molecular biology (Clifton, N.J.) · 2023
via PubMed
Wikidata facts
Show 1 more fact
- EC enzyme number
- 3.4.24.-
Sources (3)
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Therapeutic uses
- The MEROPS M9 family
- Other uses
- See also
- References
- External links
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.
Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.