Structure via PubChem · Public domain (PubChem)
D-(-)-mannitol
Sign in to saveAlso known as Aridol Kit, Resectisol, e421, Fraxinine, (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol, D-Mannitol, Mannite, Manna Sugar
Mannitol is a type of sugar alcohol used as a sweetener and medication. It is used as a low-calorie sweetener as it is poorly absorbed by the intestines. As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure. Medically, it is given by injection or inhalation. Effects typically begin within 15 minutes and last up to 8 hours.
Key facts
- Drug.verifiedrevid
- 456482551
- Drug.image
- D-Mannitol structure.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Mannitol-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Osmitrol, Bronchitol, others
- Drug.DailyMedID
- Mannitol
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- Intravenous, by mouth, inhalation
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AD16
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- ~7%
- Drug.metabolism
- Liver, negligible
- Drug.elimination_half life
- 100 minutes
- Drug.excretion
- Kidney: 90%
via Wikipedia infobox
Chemical data
- Formula
- C6H14O6
- Molecular weight
- 182.17 g/mol
- IUPAC name
- (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
- SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- InChIKey
- FBPFZTCFMRRESA-KVTDHHQDSA-N
- XLogP
- -3.1
- Polar surface area
- 121 Ų
- H-bond donors
- 6
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
26,883 papers- Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.Food research international (Ottawa, Ont.) · 2020
- D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.Cells · 2021
- Liquid-liquid transition kinetics in D-mannitol.The Journal of chemical physics · 2022
- D-mannitol metabolism by Aspergillus candidus.Journal of bacteriology · 1969
- [Characterization of a D-mannitol oxidase from Paenibacillus sp. and its application in the preparation of D-mannose].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2023
via PubMed
Wikidata facts
- Mass
- 182.079
Show 6 more facts
- defined daily dose
- 0.8
- chemical formula
- C₆H₁₄O₆
- isomeric SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- canonical SMILES
- C(C(C(C(C(CO)O)O)O)O)O
- Commons category
- Mannitol
- melting point
- 166
Sources (7)
via Wikidata · CC0
~13 min read
Article
20 sectionsContents
- Uses
- Medical uses
- Injected
- Inhaled
- Oral
- Food
- Analytical chemistry
- Other
- Contraindications
- Chemistry
- Production
- Industrial synthesis
- Biosyntheses
- Natural extraction
- History
- Controversy
- Compendial status
- See also
- References
- External links
Mannitol is a type of sugar alcohol used as a sweetener and medication. It is used as a low-calorie sweetener as it is poorly absorbed by the intestines. As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure. Medically, it is given by injection or inhalation. Effects typically begin within 15 minutes and last up to 8 hours.
Common side effects from medical use include electrolyte problems and dehydration. Other serious side effects may include worsening heart failure and kidney problems. It is unclear if use is safe in pregnancy. Mannitol is in the osmotic diuretic family of medications and works by pulling fluid from the brain and eyes.