Structure via PubChem · Public domain (PubChem)
داکتینومایسین
Sign in to saveAlso known as Cosmegen, ActD, Actinomycin D, 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-I)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide, Actinomycin iv, Meractinomycin, Actinomycin C1, GNF-Pf-1977
Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer. This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovarian cancer. It is given by injection into a vein.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477241639
- Drug.IUPAC_name
- 2-Amino-N,''- bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H''-phenoxazine-1,9-dicarboxamide
- Drug.image
- Actinomycin C1.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Actinomycin D sticks.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Cosmegen
- Drug.MedlinePlus
- a682224
- Drug.pregnancy_AU
- D
- Drug.pregnancy_US
- D
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.routes_of_administration
- IV
- Drug.protein_bound
- 5%
via Wikipedia infobox
Chemical data
- Formula
- C62H86N12O16
- Molecular weight
- 1255.4 g/mol
- IUPAC name
- 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
- SMILES
- C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
- InChIKey
- RJURFGZVJUQBHK-IIXSONLDSA-N
- XLogP
- 3.8
- Polar surface area
- 356 Ų
- H-bond donors
- 5
- H-bond acceptors
- 18
- Formal charge
- 0
via PubChem
Research
19,514 papers- Dactinomycin potentiation of radiation pneumonitis: a forgotten interaction.Pediatric hematology and oncology · 1991
- Dactinomycin in acute myeloid leukemia with NPM1 mutations.European journal of haematology · 2020
- Dactinomycin.The Medical letter on drugs and therapeutics · 1965
- Correction: Dactinomycin dose.Annals of internal medicine · 1983
- [Importance of dactinomycin in the current therapy of tumors].Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology · 1985
via PubMed
Wikidata facts
- Has part
- nitrogen
- Mass
- 1254.628
- Has use
- medication
Show 7 more facts
- chemical formula
- C₆₂H₈₆N₁₂O₁₆
- medical condition treated
- Ewing sarcoma
- subject has role
- essential medicine
- isomeric SMILES
- C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
- canonical SMILES
- CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
- Commons category
- Dactinomycin
- stylized name
- DACTINomycin
Sources (9)
via Wikidata · CC0