DEFA1B
Sign in to saveAlso known as HNP-1, HP-1, HP1, defensin alpha 1B
Defensin, alpha 1B a human protein that is encoded by the DEFA1B gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to DEFA1B, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.
Vinony files it under Defensins and Genes on human chromosome 8.
Vinony links it to 5 Wikipedia language editions.
Gene data
DEFA1B- Name
- defensin alpha 1B
- Type
- protein-coding
- Position
- 6,996,766–6,999,206 (−)
- Aliases
- HNP-1, HP-1, HP1
- Ensembl
- ENSG00000285176
- RefSeq RNA
- NM_001042500.2, NM_001302265.2
- RefSeq protein
- NP_001035965.1, NP_001289194.1
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
defensin alpha 1B
- Symbol
- DEFA1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:6,996,766-6,999,206
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- exact match
- identifiers.org/ncbigene/728358
- HomoloGene ID
- 128756
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 8
- genomic end
- 6999198
- genomic start
- 6873391
- cytogenetic location
- 8p23.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Defensin, alpha 1B a human protein that is encoded by the DEFA1B gene.
== See also == defensin
Excerpted from Wikipedia’s “DEFA1B” article, available under the CC BY-SA 4.0 licence.