Desmin
Sign in to saveAlso known as DES, epididymis secretory sperm binding protein, intermediate filament protein, cardiomyopathy, dilated 1F (autosomal dominant), mutant desmin p.K241E, uniprot:P17661
Desmin is a protein that in humans is encoded by the DES gene. Desmin is a muscle-specific, type III intermediate filament that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture.
Protein · UniProt
Desmin
- Gene
- DES
- Organism
- Homo sapiens (Human)
- Length
- 470 aa
- Molecular mass
- 53,536 Da
- Evidence
- 1: Evidence at protein level
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, Pu…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- NAUNKNOWNRelationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and PrognosisMinistry of Scientific Research and Information Technology, Poland · NCT00819442
~6 min read
Article
5 sectionsContents
- Structure
- Function
- Clinical significance
- References
- External links
Desmin is a protein that in humans is encoded by the DES gene. Desmin is a muscle-specific, type III intermediate filament that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture.
== Structure ==