desmosterol
Sign in to saveAlso known as 3beta-cholesta-5,24-dien-3-ol, Cholest-5,24-dien-3beta-ol, Cholesta-5,24-dien-3b-ol, Cholesta-5,24-dien-3-ol, (1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
Desmosterol (cholesta-5,24-dien-3β-ol) is a lipid present in the membrane of phytoplankton and an intermediate product in cholesterol synthesis in mammal cells. Structurally, desmosterol has a similar backbone to cholesterol, with the exception of an additional double bond in the structure of desmosterol.
Research
867 papers- Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2021
- DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice.iScience · 2024
- Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.Progress in lipid research · 2013
- Desmosterol-driven atypical macrophage polarization regulates podocyte dynamics in diabetic nephropathy.Molecular biology reports · 2024
- Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.Nature medicine · 2013
via PubMed
Wikidata facts
- Mass
- 384.339216
Show 6 more facts
- found in taxon
- house mouse
- chemical formula
- C₂₇H₄₄O
- canonical SMILES
- CC(CCC=C(C)C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
- isomeric SMILES
- C[C@H](CCC=C(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
- Commons category
- Desmosterol
- subject has role
- primary metabolite
via Wikidata · CC0
~7 min read
Encyclopedic overview
12 sectionsContents
- Background
- Biological occurrence
- Biosynthesis
- Preservation
- Use as a Biomarker
- Balsfjorden, Northern Norway
- Peruvian Shelf
- Measurement techniques
- GC-MS
- Ozonolysis
- See also
- References
Desmosterol (cholesta-5,24-dien-3β-ol) is a lipid present in the membrane of phytoplankton and an intermediate product in cholesterol synthesis in mammal cells. Structurally, desmosterol has a similar backbone to cholesterol, with the exception of an additional double bond in the structure of desmosterol.
The similarity can be seen biologically through the synthesis of cholesterol in the human body, as desmosterol is the immediate precursor to cholesterol in the Bloch pathway. Desmosterol is accumulated in desmosterolosis and undergoes reduction with the enzyme 24-dehydrocholesterol reductase to form cholesterol.
Excerpted from Wikipedia’s “desmosterol” article, available under the CC BY-SA 4.0 licence.