File:Diazepam_structure.svg · Wikimedia Commons · See Wikimedia Commons
Diazepam
Sign in to saveAlso known as Diastat®, LA-III, Valium®, WY-3467, Methyl diazepinone, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
benzodiazepin türevi ilaç
OverviewAI-generated
Diazepam is a chemical compound with the formula C₁₆H₁₃ClN₂O. Its IUPAC name is 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. The stylized name for the substance is diazePAM.
The compound has a mass of 284.072 and a weight of 284.74. It possesses a charge of 0, an xlogp of 3, and a tpsa of 32.7. Diazepam has 0 hydrogen bond donors and 2 hydrogen bond acceptors. The defined daily dose is 10.
The subject is referenced by 1,913 other encyclopedia articles. A query for diazepam in PubMed yields a count of 28056.
Synthesized by Vinony from 19 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443634166
- Drug.image
- Diazepam structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Diazepam-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Valium, others
- Drug.MedlinePlus
- a682047
- Drug.DailyMedID
- Diazepam
- Drug.pregnancy_AU
- C
- Drug.dependency_liability
- High
- Drug.addiction_liability
- Moderate
- Drug.routes_of_administration
- Oral, intramuscular, intravenous, rectal, intranasal, buccal
- Drug.class
- Benzodiazepine
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- BA01
via Wikipedia infobox
Chemical data
- Formula
- C16H13ClN2O
- Molecular weight
- 284.74 g/mol
- IUPAC name
- 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
- InChIKey
- AAOVKJBEBIDNHE-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1963
- Admin. routes
- oral, parenteral, topical
- Indications
- epilepsy, Seizure, anxiety, pain
via ChEMBL · EBI
Research
28,056 papers- Comparison of the actions of diazepam and lorazepam.British journal of anaesthesia · 1979Dundee JW, McGowan WA, Lilburn JK et al.DOI: 10.1093/bja/51.5.439
- Diazepam in the Elderly: Looking Back, Ahead, and at the Evidence.Journal of clinical psychopharmacology · 2020Greenblatt DJ, Harmatz JS, Shader RIDOI: 10.1097/JCP.0000000000001213
- Diazepam and breathlessness.Lancet (London, England) · 1980
- Diazepam in the treatment of organophosphorus ester pesticide poisoning.ReviewToxicological reviews · 2003Marrs TCDOI: 10.2165/00139709-200322020-00002
- Safety and efficacy of diazepam autoinjector for the management of epilepsy.ReviewExpert review of neurotherapeutics · 2015Verrotti A, Milioni M, Zaccara GDOI: 10.1586/14737175.2015.1003043
- Diazepam (Valium): its dependency liability.ReviewThe Journal of psychology · 1990Murray JBDOI: 10.1080/00223980.1990.10543259
- Diazepam and breast-feeding.Lancet (London, England) · 1972Erkkola R, Kanto JDOI: 10.1016/s0140-6736(72)90954-3
- [Diazepam in obstetrics].ReviewDuodecim; laaketieteellinen aikakauskirja · 1973Erkkola R, Kanto J
via PubMed
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 284.072
- Manufacturer
- Pfizer
- Image
- Diazepam structure.svg
- Has use
- medication
Show 12 more facts
- Commons category
- Diazepam
- route of administration
- enteral administration
- chemical formula
- C₁₆H₁₃ClN₂O
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
- found in taxon
- Physalis angulata
- subject has role
- benzodiazepine drug
- has characteristic
- bitterness
- stylized name
- diazePAM
- defined daily dose
- 10
- legal status (medicine)
- boxed warning
- significant drug interaction
- loxapine
- World Health Organisation international non-proprietary name
- diazepamum
Sources (12)
via Wikidata · CC0