Structure via PubChem · Public domain (PubChem)
loxapine
Sign in to saveAlso known as Adasuve®, CL-62362, CL-71563, Loxapac®, Loxitane®, SUM-3170, Loxapina, Cloxazepine
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia and bipolar disorder. It is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.
Key facts
- Drug.UNII
- LER583670J
- Drug.KEGG
- D02340
- Drug.ChEBI
- 50841
- Drug.ChEMBL
- 831
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 408581688
- Drug.image
- Loxapine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Loxapine ball-and-stick model from xtal 1977.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Loxitane, Adasuve
- Drug.MedlinePlus
- a682311
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Loxapine
- Drug.licence_US
- Loxapine
via Wikipedia infobox
Chemical data
- Formula
- C18H18ClN3O
- Molecular weight
- 327.8 g/mol
- IUPAC name
- 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
- SMILES
- CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
- InChIKey
- XJGVXQDUIWGIRW-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 28.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
892 papersvia PubMed
Wikidata facts
- Mass
- 327.114
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₈H₁₈ClN₃O
- Commons category
- Loxapine
- legal status (medicine)
- boxed warning
- medical condition treated
- schizophreniform disorder
- canonical SMILES
- CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
- subject has role
- antipsychotics
- significant drug interaction
- sodium oxybate
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Available forms
- Side effects
- Pharmacology
- Mechanism of action
- Use as an inhaled agitation medication
- Pharmacokinetics
- Chemistry
- References
- External links
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia and bipolar disorder. It is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.
Loxapine may be metabolized by N-demethylation to amoxapine, a tricyclic antidepressant.
Excerpted from Wikipedia’s “loxapine” article, available under the CC BY-SA 4.0 licence.